Cisplatin renal clearance
WebApr 19, 2024 · The mean renal clearance of cisplatin exceeds creatinine clearance and was 62 mL/min per m² and 50 mL/min per m² following administration of 100 mg/m² as 2-hour or 6-to 7-hour infusions, respectively. Plasma concentrations of the parent compound, cisplatin, decrease monoexponentially with a half-life of about 20 to 30 minutes … WebMar 2, 2024 · After several decades, cisplatin continues to be an essential drug for the treatment of several tumors, however, its potential nephrotoxicity is still a clinically relevant issue. Identification of predisposing factors for renal toxicity could be of value to warrant prophylactic measures. We analyzed data from 198 patients with various tumor types, …
Cisplatin renal clearance
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WebAug 1, 2005 · The renal clearance of a chemotherapeutic agent is important in CRRT-dependent patients. However, clearance of a particular drug by dialysis is not necessarily predicted by its renal clearance in patients with normal renal function. ESRD and dialysis can affect drug clearance in more ways than simple first-order kinetics. WebFeb 16, 2024 · This drug can cause severe renal toxicity, including acute renal failure. Severe renal toxicities are dose-related and cumulative. Ensure adequate hydration and …
WebNational Center for Biotechnology Information WebPretreatment with cisplatin has been reported to increase MTX toxicity, possibly by decreasing renal clearance (40). AKI prolongs extrarenal toxicity (myelosuppression …
WebFeb 16, 2016 · We consider creatinine clearance a more accurate indicator than serum creatinine levels as it takes bodyweight into account. Nephrotoxicity during CCRT (Glomerular Filtration Rate [GFR] <50 mL/min) may require cisplatin dose reductions. This in turn, however, may lead to poorer treatment outcomes. WebSep 15, 2024 · Cisplatin is a prescription medicine used to treat the symptoms of cancer in the testicles (Metastatic Testicular Tumors), bladder (Advanced Bladder Cancer) and ovaries (Metastatic Ovarian Carcinoma). Cisplatin may be …
WebSep 1, 2014 · Overexpression of Sirt1, a NAD-dependent protein deacetylase, in the proximal tubule cell maintains peroxisome number and reduces renal reactive oxygen species levels which rescued cell apoptosis induced by cisplatin . Downregulation of Klotho gene, an anti-aging gene expressed in the distal convoluted tubules, was observed in …
WebSerum creatinine, blood urea nitrogen, electrolyte, and glomerular filtration rate (GFR) were measured at baseline and days 2 and 7. Moreover, GFR was calculated based on the 24-hour urine creatinine clearance rate to assess renal function at baseline and 48 hours after receiving cisplatin. porky the gob redrawnWebCisplatin dose adjustment in patients with renal impairment must be improved. Estimating GFR with the aMDRD formula and adding an intermediary level of dose reduction for … sharp multimedia projectorsWebRenal function of cancer patients "fit" for Cisplatin chemotherapy: physician perspective Authors J Montoya 1 , H G Luna 2 , J R Amparo 2 , C Casasola 3 , G Cristal-Luna 2 Affiliations 1 Joey Montoya, MD, National Kidney and Transplant Institute, Philippines. porky the pig sings blue christmasWebApr 12, 2024 · OCT2 exerts its action through cisplatin transport into renal tubular epithelial cells . Consequently, OCT2 is responsible for the cellular uptake of cisplatin and, thus, for its intracellular accumulation. ... Indeed, from 5% to 15% of the patients with both estimated creatinine clearance (eCrCl), expressed in milliliters/minute, ... sharp multifunctionWebThe mean renal clearance of cisplatin exceeds creatinine clearance and is 62 and 50 mL/min/m 2 following administration of 100 mg/m 2 as 2 hour or 6 hour to 7 hour infusions, respectively. The renal clearance of free … sharp mp-a100WebIn general, any patient with a GFR70 mL/min should be highlighted as ‘at risk’ from cisplatin renal toxicity. Kintzel PE, Dorr RT. Anticancer drug renal toxicity and elimination: dosing … porky tracks n snacks s1 e3WebThe renal clearance of free (ultrafilterable) platinum also exceeds the glomerular filtration rate indicating that cisplatin or other platinum-containing molecules are … porky the pig says bich