Cisplatin transporter
WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in … WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different …
Cisplatin transporter
Did you know?
WebOct 5, 2014 · The uptake of cisplatin is mediated by the copper transporter Ctr1 in yeast and mammals (Ishida, Lee et al., 2002). It has been further confirmed in human cells that cisplatin triggers rapid degradation of the copper membrane transporter CTR1, with diminished influx of cisplatin, resulting in resistance to the drug ( Lin, Okuda et al., 2002 ... WebCisplatin is mainly internalised by the copper transporter CTR1. Accordingly, CTR1 down-regulation has been associated with resistance to platinum-based drugs in cancer [ 10 , 11 ]. Cellular inactivation of cisplatin and subsequent sequestration can be mediated by binding to cytoplasmic nucleophilic factors, including glutathione (GSH) and ...
WebJul 1, 2024 · The remaining cisplatin can transport to tumor cells by passive diffusion through plasma membrane [31], [44], [47]. Modern studies reveal that copper transporter protein CTR1 is also responsible for cisplatin uptake [48]. Cisplatin causes degradation of concentration of CRT1, resulting in lower cisplatin accumulation by the cancer cells. WebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 …
WebThe copper transporter 1 seems to be of particular importance for cisplatin uptake in tumor cells, while the organic cation transporter (OCT) 2, due to its specific organ distribution, may play a major role in the development of undesired cisplatin side effects. WebApr 14, 2024 · HIGHLIGHTS. who: ICP-TOF et al. from the Autonomous University of Madrid, Spain have published the research: The copper transporter CTR1 and cisplatin accumulation at the single-cell level by LA-ICP-TOFMS, in the Journal: (JOURNAL) what: In this study, total CTR1 levels (comprising plasma_membrane-associated and intracellular …
WebOct 7, 2002 · Cisplatin is a chemotherapeutic drug used to treat a variety of cancers. Both intrinsic and acquired resistance to cisplatin, as well as toxicity, limit its effectiveness. …
WebFeb 23, 2007 · Ctr1, the major copper influx transporter, has been convincingly demonstrated to transport cisplatin and its analogues, carboplatin, and oxaliplatin. Evidence also suggests that the two copper efflux transporters ATP7A and … how many calories in korean bibimbapWebJan 17, 2024 · System x c − is one among many amino acid transporters expressed in the plasma membrane of mammalian cells 1.This transporter is composed of xCT (SLC7A11), which is the substrate-specific ... how many calories in kunafaWebThese transporters have a large binding site containing partially overlapping interaction domains for different substrates and are specifically distributed around the body. … how many calories in kozy shack rice puddingWebHydroxytyrosol protects against cisplatin-induced nephrotoxicity via attenuating CKLF1 mediated inflammation, and inhibiting oxidative stress and apoptosis. ... of cisplatin in suppression of hepatocellular carcinoma via inhibiting CKLF1 mediated NF-κ B pathway and regulating transporter mediated drug efflux. Journal of Ethnopharmacology, 2024 ... how many calories in kurkureWebFeb 10, 2024 · Cisplatin is a chemotherapeutic drug widely used to treat various types of cancers, including testicular, ovarian, bladder, head and neck, lung, and cervical cancers. However, patients treated with cisplatin frequently suffer from nausea, vomiting, fatigue, serious kidney problems, tinnitus and hearing loss. high rise invasion gif pfpWebFeb 23, 2007 · Ctr1, the major copper influx transporter, has been convincingly demonstrated to transport cisplatin and its analogues, carboplatin, and oxaliplatin. … how many calories in kraft cheeseWebApr 24, 2015 · Cisplatin seems to interact preferentially with hOCT2 (Ciarimboli et al., 2005), suggesting that hOCT2 is the critical transporter for renal cisplatin uptake in … how many calories in kopparberg