Cyclodehydratases
WebSep 15, 2024 · Abstract In nature, azolines produced by YcaO cyclodehydratases during the biosynthesis of ribosomally synthesized and post-translationally modified peptides … WebApr 1, 2024 · Cyclases, such as lanthionine synthetases, cyclodehydratases, ATP-grasp ligases, and various other families of macrocyclases, generally tolerate a wide variety of sequence contexts and have been the most often-applied modification enzymes to randomized peptide libraries [2].
Cyclodehydratases
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WebApr 17, 2015 · Class II enzymes are generically named LanMs, which are single polypeptides containing an N-terminal dehydratase domain that bears no homology to any functionally known enzymes and a C-terminal LanC-like cyclase domain ( 13, 14 ). Class III and class IV synthetases are trifunctional enzymes termed LanKC ( 15) and LanL ( 16 ), … WebJun 17, 2010 · Recently, the importance of cyclodehydratases in the production of therapeutics has been emphasized by the independent discovery by several groups that …
WebTo investigate whether YcaO cyclodehydratases precisely recognize the common structural characteristics and chirality of the modifiable residues, the “reprogrammed FIT‐PatD system” has been established by combining a YcaO cyclodehydratase (PatD) with genetic code reprogramming powered by the flexible in vitro translation (FIT) system, in ... WebCyclodehydratases and dehydrogenases represent an exceptionally well-studied class of RiPP enzymes. 3 These enzymes work together to catalyze intramolecular cyclization 3,4 and subsequent...
WebThe oxidation (dehydrogenation) of thiazoline to thiazole is common in natural products, especially in RiPPs. 543, 546 The tendency for RiPP BGCs to install thiazoles may … WebJan 21, 2014 · Thiazoles and oxazoles are installed by the successive action of an ATP-dependent cyclodehydratase (C- and D-protein) and a FMN-dependent dehydrogenase (B-protein), which are responsible for azoline formation and azoline oxidation, respectively.
WebThe meaning of CYCLODEHYDRATION is cyclization involving chemical dehydration. Love words? You must — there are over 200,000 words in our free online dictionary, but you …
WebJul 10, 2024 · Cyclodehydratases are a type of RiPP modifying enzyme that catalyze phosphorylation of the peptide backbone and subsequent nucleophilic attack by … camille kosinskiWebRiPP enzymes known as cyclodehydratases and dehydrogenases work together to catalyze intramolecular, inter-residue condensation and dehydrogenation reactions that install oxazoline/oxazole and... camille kitchen hamilton njWebNov 1, 2010 · While the typical core set of thiopeptide modification enzymes contains one cyclodehydratase/dehydrogenase pair, paralogous genes predicted to encode additional cyclodehydratases and... camille lassalle kineWebJan 6, 2024 · Abstract. Ribosomally synthesized and post-translationally modified peptides (RiPPs) are peptide-derived natural products that include the FDA-approved analgesic … camille kostek si photosWebJan 15, 2024 · Abstract In nature, azolines produced by YcaO cyclodehydratases during the biosynthesis of ribosomally synthesized and post-translationally modified peptides … camille kuonyWebCyclodehydratases and dehydrogenases represent an excep- tionally well-studied class of RiPP enzymes.3These enzymes work together to catalyze intramolecular … camille kylianWebMar 17, 2024 · Of these enzymes, cytochromes P450 (P450s) are a superfamily of heme-thiolate proteins involved in many metabolic pathways, including RiPP biosyntheses. In this review, we focus our discussion on P450 involved in RiPP pathways and the unique chemical transformations they mediate. camille kyle