WebTo enable well-powered studies in mice, high-density genotypes for inbred strains of mice using the Mouse Diversity Array are generated, which increase marker density by 1.9-fold, have reduced missing data rates, and provide more accurate identification of heterozygous regions compared with previous genotype data. Human genome-wide association … WebOver the last few years, we have typed the hybrid mouse diversity panel (HMDP) strains for a variety of clinical traits as well as intermediate phenotypes, and have shown that the …
The Hybrid Mouse Diversity Panel: a resource for systems …
Web4 apr. 2024 · Figure. Identification of Ascc2 as a causal gene for heart failure with preserved ejection fraction. A, Identification of Ascc2 as a cis-regulator of diastolic function.Ai, Experimental design for the development of isoproterenol (ISO)–induced cardiomyopathy across hybrid mouse diversity panel (HMDP) strains.Nine-week-old female mice from … Web15 aug. 2012 · The hybrid mouse diversity panel (HMDP) consists of a population of over 100 inbred mouse strains selected for usage in systematic genetic analyses of complex traits (Table 1).Our goals in selecting the strains were to (1) increase resolution of genetic mapping, (2) have a renewable resource that is available to all investigators worldwide, … bud\u0027s ss
Genetic Architecture of Heart Mitochondrial Proteome influencing ...
WebDuring the past 10 years, we have developed a unique mapping approach in mice that is analogous to genome-wide association studies in humans. This approach utilizes a well … Web4 apr. 2024 · Figure. Identification of Ascc2 as a causal gene for heart failure with preserved ejection fraction. A, Identification of Ascc2 as a cis-regulator of diastolic function.Ai, Experimental design for the development of isoproterenol (ISO)–induced cardiomyopathy across hybrid mouse diversity panel (HMDP) strains.Nine-week-old female mice from … Web14 mrt. 2024 · The Hybrid Mouse Diversity Panel (HMDP) is a collection of approximately 100 well-characterized inbred strains of mice that can be used to analyze the genetic … bud\u0027s spring service