Sumo interaction motifs sims
Web2 May 2016 · The binding site on SUMO1 represents a unique epitope for SUMO interaction spatially opposite to that observed for canonical SUMO … Web17 Sep 2024 · A large number of yeast proteins is known to interact non-covalently with SUMO via short SUMO-interacting motifs (SIMs), but the structural details of this interaction are yet poorly characterized.
Sumo interaction motifs sims
Did you know?
Web19 Oct 2024 · Another study also indicated that ψ-K-x-E\D (where D is an aspartic acid) 12,13 was the consensus motif and reported that 26% (69/268) of SUMO sites did not follow … Web11 Oct 2010 · Additionally, non-covalent SUMO interacting motifs (SIMs) have been identified within most SUMO E3 ligases [33,34,35]. SIMs are characterized by Ψ-X-Ψ-Ψ where Ψ is V/I or another large hydrophobic residue [34,36]. ... This sequence has been proposed to function in aiding E3 interaction with SUMO-conjugated UBC9 (not …
Web22 Apr 2013 · Among the 4 SIM motifs of RNF4, SIM2 and SIM3 play a more important role in the interaction with poly-SUMO chains 18. These findings highlight the importance of clustered SIMs, which efficiently interact with polySUMO chains by increasing the binding capacity for SUMO, since the affinity of an isolated SIM for SUMO is usually low (2–3 μM … Web17 Aug 2015 · Protein SUMOylation has emerged as an important regulatory event, particularly in nuclear processes such as transcriptional control and DNA repair. In this context, small ubiquitin-like modifier (SUMO) often provides a binding platform for the recruitment of proteins via their SUMO-interacting motifs (SIMs).
Web30 May 2024 · Citation 1-3 The SUMO moiety is thought to mediate these effects by modulating protein–protein interactions, in some cases enabling and in other cases precluding the interactions. Proteins that associate with SUMO-modified partners contain one or more SUMO-interacting motifs (SIMs), typically consisting of several hydrophobic … Web31 May 2014 · The complexity of SUMO regulations has greatly hampered the large-scale identification of SUMO substrates or interaction partners on a proteome-wide level. In this work, we developed a new...
WebRNF4 uses multiple SUMO interaction motifs (SIMs) to bind to these chains. However, in addition to polySUMO chains, a multimeric binding surface created by the simultaneous SUMOylation of multiple residues on a protein or complex could also provide a platform for the recruitment of multi-SIM proteins like RNF4.
Web1 Jun 2007 · Determinants of the SUMO-interacting motif. (A) Model of the β-grasp fold of the small ubiquitin-like modifier.Indicated are the β2 strand and α1 helix of SUMO and the groove formed between them. (B) β2 strand and α1 helix of aligned SUMO isoforms and ubiquitin (Huang et al, 2004).Conserved residues of SUMO1 that command hydrophobic … planetary newtonianWebPosttranslational modification of proteins by the small ubiquitin-like modifier (SUMO) is a potent regulator of various cellular events. Hundreds of substrates have been identified, many of them involved in vital processes like transcriptional regulation, signal transduction, protein degradation, cell cycle regulation, DNA repair, chromatin organization, and nuclear … planetary newsWeb15 Nov 2016 · RNF4 uses multiple SUMO interaction motifs (SIMs) to bind to these chains. However, in addition to polySUMO chains, a multimeric binding surface created by the simultaneous SUMOylation of multiple residues on a protein or complex could also provide a platform for the recruitment of multi-SIM proteins like RNF4. planetary news todayplanetary occultation 2022Web1 Sep 2024 · The identification of sumoylation sites and SUMO-interacting motifs (SIMs) in proteins is fundamental for better understanding SUMOs. Here, we developed an updated … planetary octavesWeb1 Mar 2015 · Small ubiquitin-like modifier (SUMO) conjugation and interaction play an essential role in many cellular processes. A large number of yeast proteins is known to … planetary numerologyWebproteins with SUMO interaction motifs (SIMs) that facilitate non covalent interactions with SUMO. Here, ... conjugation, involving a proteolytic processing step to reveal a C terminal di glycine motif on SUMO, an E1 activating enzyme, an E2 conjugating enzyme, and the formation of an isopeptide bond between the ... planetary omnibus pdf free download