Web[ BNF, 2024; NICE, 2024] Contraindications and cautions Thiazide-like diuretics should be avoided in: People with: Refractory hypokalaemia. Hyponatraemia. Hypercalcaemia. Addison's disease. Symptomatic hyperuricaemia. Severe liver disease. Severe renal impairment — creatinine clearance of less than 30 mL/minute — due to lack of efficacy. WebSkin rash limited to the neck. Skin rash on the arm limited to the sun-exposed region. The prevalence of thiazide-related photosensitivity is estimated between 1 and 100 per 100 …
Causes Background information Hyponatraemia CKS NICE
WebThiazide Diuretics - Renal - Medbullets Step 1 Updated: 10/17/2024 Thiazide Diuretics 4.8 of 4 Ratings 25 Expert Comments Topic Podcast Michael Mattiucci None Topic Review Topic Questions 4 Evidence 3 Topic … WebThe mechanism for the antihypertensive effects of thiazides is poorly understood. One hypothesis proposed is that thiazides produce a smooth muscle vasodilator effect initiated by a reduction in plasma Na levels, which thereby reduce intracellular Ca levels in vascular smooth muscle via Na/Ca exchange (Adrogue & Madias, 2007). tsne hdbscan
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Web7 Jul 2024 · Background Previous findings on the associations of thiazide use with skin cancers were conflicting. This study aimed to examine the associations of individual … Web13 Oct 2024 · INTRODUCTION. Hyponatremia is an occasional but potentially fatal complication of diuretic therapy. Virtually all cases of severe diuretic-induced hyponatremia have been due to a thiazide-type diuretic [].A loop diuretic is much less likely to induce this problem unless the diuretic has induced volume depletion or water intake is very high … WebThiazide diuretics are a type of diuretic (a drug that increases urine flow). They act directly on the kidneys and promote diuresis (urine flow) by inhibiting the sodium/chloride cotransporter located in the distal convoluted tubule of a nephron (the functional unit of a kidney). Thiazides decrease sodium reabsorption which increases fluid loss ... tsne holidays